DOSING
Twice-daily dosing
Ferriprox® offers twice-daily dosing.
Administration with food may reduce the incidence of nausea and vomiting.
Are you optimizing Ferriprox® dosing?
Increasing the dose of Ferriprox from 75 mg/kg/day up to 99 mg/kg/day may improve efficacy in iron chelation.1,4,6¶
The incidence of neutropenia and agranulocytosis is not dose related within the therapeutic range.5
¶ The FDA-approved dosage of Ferriprox is 37.5 mg/kg to 49.5 mg/kg actual body weight, orally, twice daily with food for a total daily dose of 75 mg/kg to 99 mg/kg.
Flexible titration across the dose range helps patients reach their chelation targets
Inform patients that their urine might show a reddish/brown discoloration due to the excretion of iron. This is a very common sign of the desired effect, and it is not harmful.
Example:
Number of Ferriprox DR or Ferriprox 1000 mg tablets per day based on a 60 kg patient (rounded to the nearest half tablet)
No dosage adjustment required for patients with renal or hepatic impairment1,6
Ferriprox is suitable for patients with mild to severe renal or mild to moderate hepatic†† impairment.1,6
In clinical studies, renal or hepatic impairment had no significant effect on systemic exposure to Ferriprox.1,6
†† Ferriprox was not studied in a severely hepatically impaired patient population.
