This informational website is developed by Chiesi USA, and is intended only for residents of the United States

Ferriprox (deferiprone) is a prescription medicine used to treat iron overload from blood transfusions in people with:

  • thalassemia syndromes
  • sickle cell disease or other anemias

Ferriprox Tablets are for adults and children ≥8 years of age; Ferriprox Oral Solution is for patients ≥3 years of age.

It is not known if Ferriprox is safe and effective to treat iron overload due to blood transfusions:

  • in people with myelodysplastic syndrome or Diamond Blackfan anemia
  • in children less than 3 years of age

Learn more about Ferriprox >

Iron removal (chelation) is important for patients with thalassemia syndromes who receive repeated blood transfusions. Repeated blood transfusions cause iron to build up in the body.

Iron can build up in organs such as the heart and liver. Chelation medications have been proven to effectively remove excess iron from the body. Different chelators have different abilities in removing the iron from the heart and the liver and lowering serum ferritin (reflecting total body iron level).

Ferriprox® has been demonstrated to reduce serum ferritin, and heart and liver iron

Serum

Serum ferritin reduction

In the clinical trial, 50% of patients experienced at least a 20% reduction in serum ferritin within 1 year of therapy

Heart

Heart iron reduction¶¶

In the clinical trial, there was an increase in cardiac MRI T2* from a mean at baseline of 11.8±4.9 ms to a mean of 15.1±7.0 ms after approximately 1 year of treatment.¶¶

Liver

Liver iron reduction

In the clinical trial, 42% of patients experienced at least a 20% reduction in liver iron within 1 year of therapy.¶¶

ms = milliseconds

¶¶ The clinical significance of this observation is not known

Ferriprox is suitable for patients with mild to severe reduction in kidney function or a mild to moderate reduction in liver†† function with no need to lower the dose.

†† Ferriprox was not studied in patients with severely reduced liver function.

Learn more about iron chelation >

Heart-related problems are the leading cause of death in thalassemia patients who receive repeated blood transfusions with iron chelation that is not working well enough.

If you receive repeated blood transfusions, the American Heart Association (AHA) recommends yearly MRI T2* tests for the heart.

Different iron chelators remove iron from the heart differently. Talk to your doctor to see if Ferriprox is right for you.

Learn how Ferriprox removes extra iron from the heart >

Treatment guidelines recommend preventing significant iron loading from the start, not just in an emergency.

The American Heart Association (AHA) recommends yearly MRI T2* assessments of the heart for thalassemia patients.

Cooley's Anemia Foundation recommends LIC assessments to be completed annually.

Use the MRI T2* facility search to find the one nearest you >

Ferriprox is an oral medication that is taken either as a tablet or a liquid solution.

Ferriprox offers Twice-A-Day tablet formulations.This means you get the same iron reduction with fewer doses per day.

Talk to your healthcare provider about the formulation you prefer.

Choose your Ferriprox formulation >

Yes. Ferriprox is suitable for patients with reduced kidney or liver function. No change of the Ferriprox dose is required in patients with a mild to severe reduction in kidney function or a mild to moderate reduction in liver function.

Ferriprox was not studied in patients with severely reduced liver function.

Talk to your doctor about switching to the Ferriprox Twice-A-Day formulation >

Your doctor will do a blood test before you start Ferriprox and weekly during treatment to check your neutrophil count. Neutrophils are a type of white blood cell and are important for fighting infections. If you develop a low neutrophil count (neutropenia) your healthcare provider should check your blood counts every day until your white blood cell count improves. Your healthcare provider may temporarily stop treatment with Ferriprox if you develop neutropenia or infection.

During treatment, your doctor will also do monthly blood tests to check your liver function. If necessary they may also check your zinc levels.

Read more important information >

If you develop a fever, sore throat or mouth sores, flu-like symptoms, or chills and severe shaking follow these 3 steps:

stop

Stop the drug immediately

bottle

Seek medical attention immediately (i.e., go to the ER or your doctor)

bottle

Notify the ER provider or your doctor that you are taking a medication that can cause agranulocytosis

A wallet card with these three steps printed on it is included in every one of your Ferriprox medication shipments. To learn more or request a wallet card, call the Chiesi Total CareSM team at: 1-866-758-7071.

Visit Chiesi Total Care >

Ferriprox is available in:

    • 1000 mg Twice-A-Day tablets
    • 1000 mg Three-Times-A-Day tablets
    • 500 mg Three-Times-A-Day tablets
    • 100 mg/mL Three-Times-A-Day oral solution

Ferriprox offers a Twice-A-Day formulation.This means you get the same iron reduction with fewer doses per day. Talk to your doctor and pharmacist today about switching to the Ferriprox Twice-A-Day formulation.

Interested in switching to the Ferriprox Twice-A-Day formulation? >

Ferriprox offers a Twice-A-Day formulation.This means you get the same iron reduction with fewer doses per day. Talk to your doctor or pharmacist (1-866-758-7071) about switching to the Ferriprox Twice-A-Day formulation.

See the difference in dosing >

Chiesi Total CareSM offers one-stop patient support. A single call to your dedicated Chiesi Total Care team is all it takes to guide you through the process of getting started on Ferriprox therapy. Visit chiesitotalcare.com or call 1-866-758-7071. We’re ready to help!

Meet your support team >

IMPORTANT SAFETY INFORMATION

What is Ferriprox® (deferiprone)?

Ferriprox® (deferiprone) is a prescription medicine used to treat iron overload from blood transfusions in people with:1

  • thalassemia syndromes
  • sickle cell disease or other anemias

Ferriprox Tablets are for adults and children ≥8 years of age; Ferriprox Oral Solution is for patients ≥3 years of age.

It is not known if Ferriprox is safe and effective to treat iron overload due to blood transfusions:

  • in people with myelodysplastic syndrome or Diamond Blackfan anemia
  • in children less than 3 years of age

What is the most important information I should know about Ferriprox?

Ferriprox can cause serious side effects, including a very low white blood cell count. One type of white blood cell that is important for fighting infections is called a neutrophil. If your neutrophil count is low (neutropenia), you may be at risk of developing a serious infection that can lead to death. Neutropenia is common with Ferriprox and can become severe in some people. Severe neutropenia is known as agranulocytosis. If you develop agranulocytosis, you will be at risk of developing serious infections that can lead to death.

Your healthcare provider should do a blood test before you start Ferriprox and weekly during treatment to check your neutrophil count. If you develop neutropenia, your healthcare provider should check your blood counts every day until your white blood cell count improves. Your healthcare provider may temporarily stop treatment with Ferriprox if you develop neutropenia or infection.

Stop taking Ferriprox and get medical help right away if you develop any of these symptoms of infection: fever, sore throat or mouth sores, flu-like symptoms, or chills and severe shaking.

What is Ferriprox® (deferiprone)?

Ferriprox® (deferiprone) is a prescription medicine used to treat iron overload from blood transfusions in people with:1

  • thalassemia syndromes
  • sickle cell disease or other anemias

Ferriprox Tablets are for adults and children ≥8 years of age; Ferriprox Oral Solution is for patients ≥3 years of age.

It is not known if Ferriprox is safe and effective to treat iron overload due to blood transfusions:

  • in people with myelodysplastic syndrome or Diamond Blackfan anemia
  • in children less than 3 years of age

Important Safety Information

Do not take Ferriprox if you are allergic to deferiprone or any of the ingredients in Ferriprox.

Before you take Ferriprox, tell your healthcare provider about all of your medical conditions, including if you: have liver problems, are pregnant or plan to become pregnant. Ferriprox can harm your unborn baby. You should avoid becoming pregnant during treatment with Ferriprox. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Ferriprox. For females who are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with Ferriprox. You should use effective birth control during treatment with Ferriprox and for at least 6 months after the last dose. For males with female partners who are able to become pregnant, you should use effective birth control during treatment with Ferriprox and for at least 3 months after the last dose. Talk to your doctor if you are breastfeeding or plan to breastfeed. It is not known if Ferriprox passes into your breast milk. Do not breastfeed during treatment with Ferriprox and for at least 2 weeks after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Avoid drinking alcohol during treatment with Ferriprox tablets (2 times a day). This may cause a faster release of the medicine.

What are other possible side effects of Ferriprox?

Ferriprox can cause serious side effects, including increased liver enzyme levels in your blood. Your healthcare provider should do monthly blood tests to check your liver function during treatment with Ferriprox.

Ferriprox can cause decreased levels of zinc in your blood. Your healthcare provider will do blood tests to check your zinc levels during treatment with Ferriprox and may prescribe a zinc supplement for you if your zinc levels are low.

The most common side effects of Ferriprox in people with thalassemia include nausea, vomiting, stomach-area (abdominal) pain, joint pain, abnormal liver function tests and low white blood cells.

The most common side effects of Ferriprox in people with sickle cell disease or other anemias include fever, stomach-area (abdominal) pain, bone pain, headache, vomiting, pain in arms or legs, sickle cell anemia with crisis, back pain, abnormal liver function tests, joint pain, mouth and throat pain, common cold, low white blood cells, cough and nausea.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

Please see Full Prescribing Information, including boxed WARNING, and Medication Guide.

IMPORTANT SAFETY INFORMATION

What is Ferriprox® (deferiprone)?

Ferriprox® (deferiprone) is a prescription medicine used to treat iron overload from blood transfusions in people with:1

  • thalassemia syndromes
  • sickle cell disease or other anemias

Ferriprox Tablets are for adults and children ≥8 years of age; Ferriprox Oral Solution is for patients ≥3 years of age.

It is not known if Ferriprox is safe and effective to treat iron overload due to blood transfusions:

  • in people with myelodysplastic syndrome or Diamond Blackfan anemia
  • in children less than 3 years of age

What is the most important information I should know about Ferriprox?

Ferriprox can cause serious side effects, including a very low white blood cell count. One type of white blood cell that is important for fighting infections is called a neutrophil. If your neutrophil count is low (neutropenia), you may be at risk of developing a serious infection that can lead to death. Neutropenia is common with Ferriprox and can become severe in some people. Severe neutropenia is known as agranulocytosis. If you develop agranulocytosis, you will be at risk of developing serious infections that can lead to death.

Your healthcare provider should do a blood test before you start Ferriprox and weekly during treatment to check your neutrophil count. If you develop neutropenia, your healthcare provider should check your blood counts every day until your white blood cell count improves. Your healthcare provider may temporarily stop treatment with Ferriprox if you develop neutropenia or infection.

Stop taking Ferriprox and get medical help right away if you develop any of these symptoms of infection: fever, sore throat or mouth sores, flu-like symptoms, or chills and severe shaking.

What is Ferriprox® (deferiprone)?

Ferriprox® (deferiprone) is a prescription medicine used to treat iron overload from blood transfusions in people with:1

  • thalassemia syndromes
  • sickle cell disease or other anemias

Ferriprox Tablets are for adults and children ≥8 years of age; Ferriprox Oral Solution is for patients ≥3 years of age.

It is not known if Ferriprox is safe and effective to treat iron overload due to blood transfusions:

  • in people with myelodysplastic syndrome or Diamond Blackfan anemia
  • in children less than 3 years of age

Important Safety Information

Do not take Ferriprox if you are allergic to deferiprone or any of the ingredients in Ferriprox.

Before you take Ferriprox, tell your healthcare provider about all of your medical conditions, including if you: have liver problems, are pregnant or plan to become pregnant. Ferriprox can harm your unborn baby. You should avoid becoming pregnant during treatment with Ferriprox. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Ferriprox. For females who are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with Ferriprox. You should use effective birth control during treatment with Ferriprox and for at least 6 months after the last dose. For males with female partners who are able to become pregnant, you should use effective birth control during treatment with Ferriprox and for at least 3 months after the last dose. Talk to your doctor if you are breastfeeding or plan to breastfeed. It is not known if Ferriprox passes into your breast milk. Do not breastfeed during treatment with Ferriprox and for at least 2 weeks after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.

Avoid drinking alcohol during treatment with Ferriprox tablets (2 times a day). This may cause a faster release of the medicine.

What are other possible side effects of Ferriprox?

Ferriprox can cause serious side effects, including increased liver enzyme levels in your blood. Your healthcare provider should do monthly blood tests to check your liver function during treatment with Ferriprox.

Ferriprox can cause decreased levels of zinc in your blood. Your healthcare provider will do blood tests to check your zinc levels during treatment with Ferriprox and may prescribe a zinc supplement for you if your zinc levels are low.

The most common side effects of Ferriprox in people with thalassemia include nausea, vomiting, stomach-area (abdominal) pain, joint pain, abnormal liver function tests and low white blood cells.

The most common side effects of Ferriprox in people with sickle cell disease or other anemias include fever, stomach-area (abdominal) pain, bone pain, headache, vomiting, pain in arms or legs, sickle cell anemia with crisis, back pain, abnormal liver function tests, joint pain, mouth and throat pain, common cold, low white blood cells, cough and nausea.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

Please see Full Prescribing Information, including boxed WARNING, and Medication Guide.

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